Figure 1. Summary of synonymous and nonsynonymous mutations and nucleotide substitutions in 27 PCNSL specimens.
(A) Numbers of synonymous and nonsynonymous mutations in PCNSL specimens (NA). Black and gray bars indicate nonsynonymous and synonymous substitutions, respectively. (B) Numbers of genes containing mutations in PCNSL specimens (NB). (C) Numbers of synonymous and nonsynonymous mutations per gene (NA/B). Number of synonymous/nonsynonymous substitutions (NA) were divided by the number of mutated genes (NB). Nonsynonymous (black) and synonymous substitutions (gray). (D) Frequencies of types of nucleotide substitutions in PCNSL specimens.