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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Nature. 2018 Apr 25;557(7703):62–67. doi: 10.1038/s41586-018-0058-6

Extended Data Fig. 5. Lipid binding by GSDM.

Extended Data Fig. 5

a, Effect of the GSDMA3 R132A/R145A mutation on the liposome-leakage activity, monitored by measuring DPA-chelating-induced fluorescence of released Tb3+ ion (n = 3 biological replicates). Error bars denote mean ± s.d. b, Equal processing of GSDMA3 by the 3C protease for the wild type and the α1 mutant. A representative gel of two independent experiments is shown.