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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Nature. 2018 Apr 25;557(7703):62–67. doi: 10.1038/s41586-018-0058-6

Extended Data Fig. 7. Structure-based sequence alignment.

Extended Data Fig. 7

The N-terminal region of GSDMA3 crystal structure (PDB ID: 5B5R) aligned with structures of perfringolysin O (5DIM), pneumolysin (4QQQ), haemolysin (3HVN), perforin-1 (3NSJ), complement C8 alpha (2QQH) and Plu-MAPCF (2QP2) and using the distance alignment matrix method (DALI). Helices are coloured in green, strands in cyan and loops in yellow. Vertical yellow bars indicate disordered regions in the GSDMA3-NT structure. Vertical red bars denote gaps in alignment of Plu-MACPF. Identical residues conserved among at least three proteins are highlighted in yellow. Glycines conserved among MACPF/CDCs are not conserved in GSDMA3, as highlighted in deep red.