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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Nature. 2018 Apr 25;557(7703):62–67. doi: 10.1038/s41586-018-0058-6

Fig. 2. Structure and conformational changes of the GSDMA3 pore.

Fig. 2

a, Cryo-EM map (grey) superimposed onto the atomic model of the 27-fold symmetric GSDMA3 pore at 3.8 Å resolution. b, Ribbon diagram of GSDMA3-NT in the pore conformation (left) and crystal structure of auto-inhibited GSDMA31 (right). c. Superposition of the auto-inhibited form and the pore form of GSDMA3-NT. d, Structural transitions that accompany the formation of the two β-hairpins HP1 and HP2 in the pore conformation. ED1 and ED2, extension domains 1 and 2, respectively.