Table 3.
Table of results of allele frequency evaluation in the study groups
| Gene | SNV | Variant | Case group MAF* | Control group MAF* | p value† | OR‡ |
|---|---|---|---|---|---|---|
| ADH5 | rs7669660 | NM_000671:c.*966T>C | 0.08 | 0.10 | 0.5257 | 0.77 |
| ADH5 | rs11547772 | NM_000671:c.*775T>G | 0.05 | 0.05 | 0.8938 | 0.93 |
| ADH5 | rs6827292 | NM_000671:c.*574T>C | 0.03 | 0.05 | 0.4919 | 0.68 |
| ADH5 | rs1803037 | NM_000671.4:c.*417G>A | 0.05 | 0.05 | 0.8938 | 0.93 |
| ADH4 | rs1042364 | NM_000670.4:c.*19A>G | 0.34 | 0.24 | 0.0982 | 1.57 |
| ADH4 | rs1126673 | NM_000670.4:c.1120G>A | 0.38 | 0.33 | 0.3833 | 1.25 |
| ADH4 | rs1126672 | NM_000670.4:c.1051C>T | 0.34 | 0.24 | 0.0982 | 1.57 |
| ADH4 | rs1126671 | NM_000670.4:c.925A>G | 0.38 | 0.33 | 0.3653 | 1.26 |
| ADH7 | rs284787 | NM_000673:c.*749C>T | 0.24 | 0.28 | 0.3738 | 0.79 |
| ADH7 | rs3805331 | NM_000673:c.*373T>C | 0.05 | 0.06 | 0.6708 | 0.81 |
| ADH7 | rs971074 | NM_000673.4:c.690G>A | 0.13 | 0.15 | 0.7696 | 0.91 |
| ADH7 | rs17537595 | NM_000673:c.-40T>C | 0.16 | 0.15 | 0.7518 | 1.11 |
| OPRM1 | rs6912029 | NM_000914:c.-172C>A | 0.04 | 0.05 | 0.5588 | 0.72 |
| OPRM1 | rs1799971 | NM_000914.4:c.118A>G | 0.07 | 0.07 | 0.9988 | 1.00 |
| OPRM1 | rs563649 | NM_001145287:c.-3004G>A | 0.10 | 0.10 | 0.9836 | 0.99 |
| OPRM1 | rs650245 | NM_001145286:c.*4A>G | 0.08 | 0.10 | 0.6153 | 0.82 |
| IPCEF1 | rs9479767 | NM_001130699:c.*4435T>C | 0.46 | 0.54 | 0.1777 | 0.73 |
| IPCEF1 | rs17277929 | NM_001130699:c.*3050T>C | 0.09 | 0.07 | 0.5631 | 1.30 |
| IPCEF1 | rs2236256 | NM_001130699:c.*2523G>T | 0.46 | 0.54 | 0.1777 | 0.73 |
| IPCEF1 | rs2236259 | NM_001130699:c.*2070T>C | 0.46 | 0.54 | 0.1777 | 0.73 |
| NPY | rs16139 | NM_000905.3:c.20T>C | 0.06 | 0.02 | 0.1963 | 2.52 |
| DPYSL2 | rs708621 | NM_001197293.2:c.1821T>C | 0.30 | 0.26 | 0.4142 | 1.25 |
| DPYSL2 | rs1058332 | NM_001197293:c.*1071G>A | 0.10 | 0.05 | 0.1586 | 2.09 |
| DPYSL2 | rs920633 | NM_001197293:c.*1557A>G | 0.14 | 0.09 | 0.1575 | 1.79 |
| DPYSL2 | rs17666 | NM_001197293:c.*2236A>G | 0.29 | 0.29 | 0.9738 | 1.01 |
| ALDH1A1 | rs8188000 | NM_000689:c.*455T>C | 0.07 | 0.11 | 0.2225 | 0.62 |
| ALDH1A1 | rs13959 | NM_000689.4:c.225C>T | 0.42 | 0.35 | 0.2507 | 1.33 |
| GAD2 | rs2236418 | NM_000818:c.-243A>G | 0.21 | 0.21 | 0.9968 | 1.00 |
| CYP2E1 | rs6413419 | NM_000773.3:c.535G>A | 0.01 | 0.00 | 0.2840 | NA |
| CYP2E1 | rs2515641 | NM_000773.3:c.1263C>G | 0.13 | 0.09 | 0.2695 | 1.58 |
| ANKK1 | rs17115439 | NM_178510.1:c.255T>C | 0.32 | 0.25 | 0.2264 | 1.39 |
| ANKK1 | rs4938013 | NM_178510.1:c.453A>C | 0.33 | 0.26 | 0.2061 | 1.41 |
| ANKK1 | rs7118900 | NM_178510.1:c.715G>A | 0.16 | 0.12 | 0.3990 | 1.35 |
| ANKK1 | rs4938016 | NM_178510.1:c.1324G>C | 0.36 | 0.29 | 0.2126 | 1.38 |
| ANKK1 | rs2734849 | NM_178510.1:c.1469A>G | 0.48 | 0.59 | 0.0719 | 0.65 |
| ANKK1 | rs2734848 | NM_178510.1:c.1683C>T | 0.18 | 0.15 | 0.4843 | 1.26 |
| HTR3B | rs1176744 | NM_006028.4:c.386A>C | 0.28 | 0.29 | 0.7644 | 0.92 |
| HTR3B | rs17116138 | NM_006028.4:c.547G>A | 0.04 | 0.05 | 0.5588 | 0.72 |
| HTR2A | rs9595552 | NM_001165947:c.*1542T>C | 0.07 | 0.06 | 0.8508 | 1.10 |
| HTR2A | rs6314 | NM_000621.4:c.1354C>T | 0.07 | 0.06 | 0.7846 | 1.14 |
| HTR2A | rs6313 | NM_000621.4:c.102C>T | 0.32 | 0.37 | 0.3725 | 0.80 |
| NALCN | rs8922 | NM_052867.2:c.*1454T>G | 0.22 | 0.22 | 0.9656 | 0.99 |
| NALCN | rs682767 | NM_052867.2:c.*1018T>C | 0.38 | 0.45 | 0.2296 | 0.75 |
| NALCN | rs682666 | NM_052867.2:c.*946C>T | 0.39 | 0.45 | 0.2578 | 0.76 |
| NALCN | rs9557581 | NM_052867.2:c.*931A>G | 0.38 | 0.45 | 0.2296 | 0.75 |
| NALCN | rs1289556 | NM_052867.2:c.4416A>C | 0.38 | 0.33 | 0.4210 | 1.23 |
| NALCN | rs17677552 | NM_052867.2:c.3714C>T | 0.37 | 0.30 | 0.2721 | 1.33 |
| NALCN | rs686141 | NM_052867.2:c.3570T>C | 0.27 | 0.38 | 0.0409 | 0.60 |
| CHRNA3 | rs660652 | NM_000743:c.*1114T>C | 0.36 | 0.33 | 0.5473 | 1.16 |
| CHRNA3 | rs472054 | NM_000743:c.*952T>C | 0.36 | 0.33 | 0.5536 | 1.16 |
| CHRNA3 | rs578776 | NM_000743:c.*546C>T | 0.25 | 0.24 | 0.8608 | 1.05 |
| CHRNA3 | rs1051730 | NM_000743.4:c.645C>T | 0.38 | 0.43 | 0.3940 | 0.81 |
| CHRNA3 | rs8040868 | NM_000743.4:c.159A>G | 0.42 | 0.46 | 0.4470 | 0.83 |
| CHRNA3 | rs8192475 | NM_000743.4:c.110G>A | 0.03 | 0.04 | 0.8898 | 0.92 |
| SLC6A4 | rs3813034 | NM_001045:c.*670T>G | 0.43 | 0.48 | 0.4897 | 0.85 |
| SLC6A4 | rs1042173 | NM_001045:c.*463T>G | 0.43 | 0.48 | 0.4897 | 0.85 |
| SLC6A4 | rs6354 | NM_001045:c.-922G>T | 0.18 | 0.21 | 0.5214 | 0.83 |
| COMT | rs4633 | NM_000754.3:c.186C>T | 0.46 | 0.51 | 0.3659 | 0.81 |
| COMT | rs4680 | NM_000754.3:c.472G>A | 0.46 | 0.51 | 0.3659 | 0.81 |
| COMT | rs769224 | NM_000754.3:c.597G>A | 0.04 | 0.07 | 0.1405 | 0.50 |
| COMT | rs165599 | NM_000754.3:c.*522G>A | 0.35 | 0.44 | 0.1277 | 0.69 |
| COMT | rs165728 | NM_000754.3:c.*764C>T | 0.11 | 0.17 | 0.1193 | 0.60 |
* MAF – Minor Allele Frequency
† p value – Pearson’s Chi squared test p value
‡ OR – Odds Ratio
Statistically significant results are bolded