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. 2018 Jun 19;7:e35213. doi: 10.7554/eLife.35213

Figure 3. The impact of TBV monoclonal antibody mAb-4b7 on PEV mAb-3D11 efficacy.

Figure 3.

The TBV antibody alone reduces the tail of the sporozoite distribution in mosquitoes across transmission cycles for the (A) 50% dose, (B) 65% dose and (C) 85% dose. (A–C) demonstrate that the sporozoite scores (measured on a log scale; 0 indicates no sporozoites; 1 = 1–10 sporozoites; 2 = 11–100 sporozoites; 3 = 101–1000 sporozoite and; 4 =>1000 sporozoites per mosquito) tend toward zero for successive transmission rounds. (D) The efficacy of the PEV antibodies to prevent mosquito-to-mouse-to-mosquito transmission (a percentage reduction in sporozoite infections in mosquitoes) is greatest at lower mosquito parasite densities (as assessed by sporozoite score following blood-feeding).