Table 1.
Sex, M/F | Age, yr | Race | BMI, kg/m2 | Diagnosis | Medications | Ballooning of Hepatocytes | Fibrosis | |
---|---|---|---|---|---|---|---|---|
Control | ||||||||
Subject 1 | M | 48 | White | Unknown | No pathological abnormality, colonic adenocarcinoma with liver metastasis | Not available | No | No |
Subject 2 | M | 56 | White | 24 | No pathological abnormality, colonic adenocarcinoma with liver metastasis | Acetaminophen, lisinopril, ranitidine, ropinivole | No | No |
Subject 3 | F | 51 | White | 29 | No pathological abnormality, colonic adenocarcinoma with liver metastasis | Amoxicillin, calcium, multivitamin | No | No |
NASH | ||||||||
Patient 1 | M | 53 | White | 30 | Fatty liver, NASH, cirrhosis, steatosis, diabetes | Acetylsalicylic acid, albuterol, atenolol, fluticasone, furosemide, lactulose, levofloxacin, phytonadione, potassium, rifaximin, omeprazole, spironolactone, tramadol, ursodiol, zinc | Yes | Yes |
Patient 2 | M | 64 | White | Unknown (290 lbs) | Fatty liver, cirrhosis | Acetaminophen, benzocaine, cetirizine, ciprofloxacin, fluoxetine, furosemide, lactulose, multivitamin, ofloxacin, oxycodone, oxymetazoline, pantoprazole, pramipexole, rifaximin, simethicone, spironolactone | Yes | Yes |
Patient 3 | F | 48 | White | 40.6 | Fatty liver, NASH, cirrhosis | Amoxicillin, esomeprazole, furosemide, potassium, propranolol, spironolactone, rifaximin, T3 liothyronine, T4 levothyroxine, zinc | Yes | Yes |
PBC | ||||||||
Patient 1 | M | 65 | White | 26.8 | Cirrhosis, primary biliary | Cyclobenzaprine, multivitamin, nadolol, omeprazole, simvastatin, spironolactone, trazodone, ursodiol, zinc | No | Yes |
Patient 2 | M | 67 | White | Unknown | Cirrhosis, primary biliary | Not available | No | Yes |
Patient 3 | F | 64 | White | 29.2 | Cirrhosis, primary biliary | Calcium, furosemide, lactulose, potassium, rifaximin, ursodiol, zinc | No | Yes |
Liver tissue from control, nonalcoholic steatohepatitis (NASH), and primary biliary cholangitis (PBC) patients was obtained from the Liver Tissue Cell Distribution System. Diagnosis was ensured by the facility pathologist. BMI, body mass index.