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GIRK current in the SAN. Left: representative traces of GIRK currents in control and after activation with 10 μM carbachol. Comparison is made between Gαi2+/+ (n = 18, 8 mice), Gαi2−/− (n = 15, 5 mice), and Gαi1/3−/− (n = 16, 7 mice). Right: mean current-voltage relationships. Atrial myocytes were challenged with 10 μM carbachol. GIRK currents were not affected by Giα deletion.
