Table 3.
Independent determinants of muscle fiber composition
| MHC-I | MHC-IIa | MHC-IIx | ||||
|---|---|---|---|---|---|---|
| β | P | β | P | β | P | |
| Men | ||||||
| Age, yr | 0.407 | <0.001 | –0.365 | <0.001 | –0.191 | 0.074 |
| BMI, kg/m2 | –0.168 | 0.088 | 0.012 | 0.904 | 0.203 | 0.057 |
| ACTN3 genotype (RR = 0, RX = 1, XX = 2) | 0.132 | 0.161 | 0.051 | 0.602 | –0.214 | 0.035 |
| ACE genotype (II = 0, ID = 1, DD = 2) | 0.221 | 0.021 | –0.123 | 0.209 | –0.170 | 0.096 |
| HIF1A genotype (CC = 0, CT = 1) | 0.151 | 0.116 | –0.153 | 0.124 | –0.054 | 0.602 |
| VEGFR2 genotype (AA = 0, AT = 1, TT = 2) | –0.110 | 0.238 | –0.026 | 0.791 | –0.116 | 0.246 |
| AGTR2 genotype (CC = 0, CA = 1, AA = 2) | 0.036 | 0.708 | –0.057 | 0.561 | 0.007 | 0.949 |
| Women | ||||||
| Age, yr | 0.264 | 0.013 | –0.119 | 0.262 | –0.239 | 0.020 |
| BMI, kg/m2 | –0.177 | 0.092 | –0.113 | 0.287 | 0.356 | <0.001 |
| ACTN3 genotype (RR = 0, RX = 1, XX = 2) | −0.076 | 0.442 | 0.084 | 0.410 | 0.019 | 0.848 |
| ACE genotype (II = 0, ID = 1, DD = 2) | −0.064 | 0.508 | 0.042 | 0.669 | 0.045 | 0.634 |
| HIF1A genotype (CC = 0, CT = 1) | 0.093 | 0.344 | 0.052 | 0.599 | –0.181 | 0.060 |
| VEGFR2 genotype (AA = 0, AT = 1, TT = 2) | 0.159 | 0.110 | –0.166 | 0.103 | –0.047 | 0.623 |
| AGTR2 genotype (CC = 0, CA = 1, AA = 2) | –0.104 | 0.282 | 0.010 | 0.916 | 0.130 | 0.167 |
Covariates included in the multiple linear regression models were age, BMI, ACTN3 R577X genotype (rs1815739), ACE I/D genotype (rs4340), HIF1A C/T genotype (rs11549465), VEGFR2 Q472H genotype (rs1870377), and AGTR2 C/A genotype (rs11091046). Values in bold denote P < 0.05.