. 2017 Dec 14;124(5):1363–1376. doi: 10.1152/japplphysiol.00474.2017

Table 3.

Metabolic and hematologic data for normobaric normoxia and hypobaric normoxia

	Normobaric Normoxia				Hypobaric Normoxia
	Rest	100 W	130 W	160 W	Rest	100 W	130 W	160 W
AaDO₂, mmHg	0.62 ± 2.16	11.4 ± 4.15	14.6 ± 5.65	17.8 ± 7.79	4.64 ± 5.13	13.4 ± 5.92	17.4 ± 8.80	19.2 ± 8.77
V̇e, l/min	15.6 ± 5.7	53.7 ± 6.6	68.9 ± 9.1	90.4 ± 19.9	11.5 ± 2.1	49.2 ± 8.8	65.3 ± 10.9	84.3 ± 8.9
V_A, l/min	8.75 ± 4.9	39.2 ± 8.1	51.4 ± 11.3	66.4 ± 19.3	7.63 ± 2.1	42.1 ± 7.2	57.8 ± 8.6	75.8 ± 12.4
V_D/V_T	0.49 ± 0.10	0.31 ± 0.10^†	0.29 ± 0.11^†	0.30 ± 0.13^†	0.49 ± 0.05	0.22 ± 0.04	0.19 ± 0.05	0.17 ± 0.09
V̇o₂, l/min	0.37 ± 0.11	1.70 ± 0.42	2.01 ± 0.45	2.33 ± 0.55	0.36 ± 0.08	1.70 ± 0.20	2.11 ± 0.17	2.47 ± 0.25
V̇co₂, l/min	0.30 ± 0.10	1.46 ± 0.30	1.85 ± 0.40	2.22 ± 0.50	0.28 ± 0.08	1.53 ± 0.20	2.02 ± 0.21	2.40 ± 0.30
RER	0.80 ± 0.09	0.87 ± 0.11	0.93 ± 0.06	0.95 ± 0.09	0.77 ± 0.07	0.90 ± 0.06	0.96 ± 0.03	0.97 ± 0.03
P_AO₂	81.2 ± 8.4	83.4 ± 4.8	86.3 ± 3.1	88.3 ± 5.8	79.7 ± 4.3	85.8 ± 5.0	87.6 ± 6.4	92.3 ± 6.0
$P a_{O}_{_{2}}$	80.6 ± 7.7	71.9 ± 6.5	71.7 ± 5.8	70.5 ± 7.5	75.0 ± 6.7	72.4 ± 6.7	70.2 ± 8.2	73.1 ± 5.8
$P a_{C O}_{_{2}}$	31.6 ± 5.1	32.2 ± 1.9	31.2 ± 2.5	29.7 ± 4.9	31.5 ± 2.6	31.8 ± 3.0	30.6 ± 4.0	27.9 ± 5.1
HR, beats/min	89 ± 19	136 ± 24	149 ± 25	158 ± 21	69 ± 12	117 ± 17	143 ± 21	159 ± 16
SV, ml	67 ± 17	82 ± 11	90 ± 18	81 ± 16	65 ± 15	78 ± 13	88 ± 14	85 ± 17
Q_T, l/min	6.0 ± 1.8	11.1 ± 2.2^†	13.3 ± 2.9	12.8 ± 2.4	4.5 ± 1.0	9.1 ± 1.8	12.4 ± 2.0	13.2 ± 2.6
PASP, mmHg	26.0 ± 6.2	38.3 ± 5.8	44.0 ± 7.4	43.8 ± 6.6	29.3 ± 3.9	37.2 ± 5.0	41.9 ± 6.1	44.0 ± 7.3
TPR, mmHg·l⁻¹·min⁻¹	4.76^*	3.55	3.42	3.47	6.73	4.21	3.44	3.39
TPR (HCT), mmHg·l⁻¹·min⁻¹	5.60^*	3.73	3.80	3.20	7.08	4.21	3.40	3.18
$S a_{O_{2}}$	95.7 ± 1.0	94.3 ± 1.5	94.3 ± 1.2	93.9 ± 1.7	94.9 ± 1.4	94.4 ± 1.5	93.7 ± 2.1	94.6 ± 2.3
$C a_{O_{2}}$ , ml O₂/dl	18.1 ± 2.2	18.2 ± 2.2	18.5 ± 1.9	18.5 ± 2.3	18.0 ± 2.6	18.3 ± 2.3	17.8 ± 2.6	18.9 ± 2.3
pH	7.46 ± 0.06	7.43 ± 0.03	7.41 ± 0.04	7.39 ± 0.06	7.45 ± 0.02	7.41 ± 0.02	7.40 ± 0.02	7.36 ± 0.06
HCT, %	39.6 ± 6.7	43.1 ± 4.2	40.9 ± 7.1	42.8 ± 4.0	43.8 ± 3.6	44.9 ± 2.9	45.5 ± 3.2	46.0 ± 3.9
tHb, g/dl	13.4 ± 1.6	13.7 ± 1.5	14.1 ± 1.2	14.1 ± 1.7	13.4 ± 1.9	13.8 ± 1.7	13.9 ± 1.8	14.4 ± 1.7
Core temp, °C	37.1 ± 0.3	37.0 ± 0.6	37.1 ± 0.6	37.3 ± 0.7	37.0 ± 0.4	37.0 ± 0.4	37.1 ± 0.6	37.3 ± 0.6
Lactate, mmol/l	1.49 ± 0.62	3.16 ± 1.55	4.24 ± 2.37	6.76 ± 3.98	1.38 ± 0.82	3.53 ± 1.55	5.22 ± 2.25	7.18 ± 2.80
n	8	8	8	7	8	8	8	8

Values are means ± SD. V_E, minute ventilation; V_A, alveolar ventilation; V_D/D_T, dead space to tidal volume ratio; V̇o₂, oxygen consumption; V̇co₂, carbon dioxide production; RER, respiratory exchange ratio; P_AO₂, partial pressure of alveolar oxygen; $P a_{O}_{_{2}}$ , partial pressure of arterial oxygen; $P a_{C O}_{_{2}}$ , arterial Pco₂; HR, heart rate; SV, stroke volume; Q_T, cardiac output; PASP, pulmonary artery systolic pressure; TPR, total pulmonary resistance (calculated); TPR (HCT), total pulmonary resistance corrected for hematocrit; $S a_{O_{2}}$ , oxygen saturation of arterial blood; $C a_{O_{2}}$ , arterial oxygen content; pH, arterial pH; Hct, arterial hematocrit; tHb, total hemoglobin; Core temp, core body temperature; lactate, arterial lactate concentration.

P < 0.05 compared with hypobaric normoxia;

^†

P < 0.05, rest vs. exercise.