Table 4.
Normobaric Hypoxia |
Hypobaric Hypoxia |
|||||||
---|---|---|---|---|---|---|---|---|
Rest | 70 W | 100 W | 130 W | Rest | 70 W | 100 W | 130 W | |
AaDO2, mmHg | 2.28 ± 1.99 | 14.6 ± 4.03 | 16.9 ± 4.26 | 20.9 ± 4.44 | 1.75 ± 2.37 | 11.1 ± 3.42 | 15.0 ± 4.83 | 17.0 ± 5.48 |
VE, l/min | 17.8 ± 3.8 | 51.5 ± 5.0 | 69.6 ± 6.4 | 101.3 ± 20.3† | 15.0 ± 3.5 | 46.3 ± 12.1 | 65.9 ± 21.3 | 82.1 ± 28.1 |
VA, l/min | 11.5 ± 3.7 | 41.7 ± 3.4 | 57.7 ± 5.1 | 87.9 ± 17.7 | 9.64 ± 2.6 | 37.1 ± 9.5 | 55.0 ± 17.6 | 71.0 ± 24.0 |
VD/VT | 0.41 ± 0.09 | 0.24 ± 0.07 | 0.23 ± 0.07 | 0.15 ± 0.05 | 0.38 ± 0.09 | 0.25 ± 0.06 | 0.23 ± 0.07 | 0.23 ± 0.08 |
V̇o2, l/min | 0.38 ± 0.08 | 1.30 ± 0.17 | 1.62 ± 0.21 | 2.06 ± 0.36 | 0.37 ± 0.09 | 1.19 ± 0.26 | 1.53 ± 0.36 | 1.77 ± 0.44 |
V̇co2, l/min | 0.36 ± 0.08 | 1.26 ± 0.12 | 1.66 ± 0.15 | 2.24 ± 0.27† | 0.30 ± 0.07 | 1.11 ± 0.26 | 1.51 ± 0.40 | 1.77 ± 0.49 |
RER | 0.94 ± 0.06 | 0.98 ± 0.05 | 1.03 ± 0.08 | 1.10 ± 0.08 | 0.83 ± 0.08 | 0.93 ± 0.08 | 0.98 ± 0.10 | 0.99 ± 0.07 |
PAO2 | 45.7 ± 4.7 | 49.6 ± 3.5 | 52.2 ± 3.3 | 55.8 ± 5.4 | 43.4 ± 2.4 | 47.8 ± 4.2 | 50.5 ± 5.6 | 52.7 ± 6.5 |
43.5 ± 5.9 | 35.0 ± 4.1 | 35.3 ± 3.8 | 35.0 ± 5.5 | 41.6 ± 1.6 | 36.6 ± 3.3 | 35.4 ± 3.5 | 35.7 ± 2.6 | |
27.4 ± 3.4 | 26.2 ± 2.7 | 25.0 ± 3.3 | 22.7 ± 5.1 | 27.5 ± 2.2 | 26.3 ± 2.8 | 24.6 ± 4.1 | 22.9 ± 5.5 | |
HR, beats/min | 102 ± 23 | 143 ± 18 | 157 ± 18 | 160 ± 22 | 82 ± 21 | 128 ± 24 | 144 ± 26 | 156 ± 21 |
SV, ml | 64 ± 11 | 82 ± 20 | 96 ± 17 | 86 ± 15 | 65 ± 11 | 88 ± 20 | 85 ± 17 | 92 ± 15 |
QT, l/min | 6.4 ± 1.4 | 11.7 ± 2.0 | 14.9 ± 2.1† | 13.5 ± 2.0 | 5.2 ± 1.1 | 11.3 ± 3.3 | 12.3 ± 3.2 | 13.6 ± 2.5 |
PASP, mmHg | 31.7 ± 7.2 | 44.2 ± 10.7 | 49.8 ± 9.0 | 50.0 ± 11.5 | 31.2 ± 6.7 | 39.6 ± 7.6 | 44.5 ± 7.1 | 42.8 ± 8.5 |
TPR, mmHg·l−1·min−1 | 5.08 | 3.90 | 3.35 | 3.71 | 6.22 | 3.77 | 3.88 | 3.19 |
TPR (HCT), mmHg·l−1·min−1 | 5.64 | 4.34 | 3.53 | 3.26 | 6.91 | 4.19 | 4.08 | 3.36 |
77.7 ± 7.2 | 65.7 ± 7.5 | 66.3 ± 6.9 | 65.6 ± 8.2 | 76.3 ± 2.1 | 68.6 ± 5.4 | 66.6 ± 5.8 | 67.3 ± 3.9 | |
, ml O2/dl | 15.0 ± 2.1 | 13.3 ± 1.1 | 13.5 ± 1.4 | 13.6 ± 1.4 | 14.9 ± 2.5 | 13.5 ± 1.6 | 12.5 ± 1.0 | 13.1 ± 1.1 |
pH | 7.50 ± 0.05 | 7.49 ± 0.03 | 7.47 ± 0.04 | 7.43 ± 0.06 | 7.50 ± 0.03 | 7.48 ± 0.03 | 7.46 ± 0.04 | 7.42 ± 0.07 |
HCT, % | 41.1 ± 4.8 | 40.6 ± 5.3 | 42.1 ± 3.9 | 44.4 ± 2.9 | 42.3 ± 4.2 | 42.1 ± 6.2 | 44.3 ± 4.6 | 43.3 ± 6.2 |
tHb, g/dl | 13.2 ± 1.5 | 13.4 ± 1.6 | 13.9 ± 1.5 | 14.3 ± 1.1 | 13.2 ± 2.0 | 13.3 ± 1.5 | 12.9 ± 1.6 | 13.6 ± 1.6 |
Core temp, °C | 37.1 ± 0.4 | 36.9 ± 0.8 | 36.9 ± 0.9 | 36.7 ± 1.1 | 37.2 ± 0.3 | 36.9 ± 0.6 | 36.9 ± 0.7 | 36.9 ± 0.8 |
Lactate, mmol/l | 1.84 ± 0.69 | 3.34 ± 0.78 | 5.23 ± 1.26 | 7.88 ± 2.26 | 1.74 ± 0.88 | 3.59 ± 1.53 | 6.11 ± 3.08 | 8.48 ± 4.81 |
n | 7 | 7 | 7 | 5 | 7 | 7 | 7 | 6 |
Values are means ± SD.
P < 0.05 rest vs. exercise.