Fig. 7.
All 3 AST-C peptides elicit a range of changes in contraction amplitude. A: when perfused through an isolated whole heart at 10−7 M, AST-C I and AST-C III caused, on average, a significant decrease in frequency. AST-C II elicited no significant overall change in amplitude (one-sample t-test, n = 53). *P < 0.05; ***P < 0.0001. Error bars indicate SE. B, C, and D: frequency histograms of the changes in amplitude recorded in response to AST-C I, II, and III, respectively. All 3 peptides include both increases and decreases in responses. Data are binned by 3% changes in all cases.