Table 2.

Physiological variables at baseline and 30-, 60-, and 90-min postintrathecal drug injections of vehicle, 5-HT_2B, 5-HT₇, or 5-HT_2B and 5-HT₇ receptor agonists in rats pretreated with apocynin

		Apocynin
	Time, min	Vehicle	5-HT2B	5-HT7	5-HT2B + 5-HT7
$P{a}_{CO}{}_{{}_2}$, mmHg	Baseline	45.7 ± 1.1	45.8 ± 1.6	43.3 ± 0.9	45.3 ± 1.3
	30	45.0 ± 1.0	46.2 ± 1.4	43.2 ± 1.2	45.9 ± 1.4
	60	45.6 ± 1.2	45.4 ± 1.6	43.4 ± 1.3	45.4 ± 1.8
	90	45.6 ± 0.9	45.6 ± 1.6	43.4 ± 1.4	44.9 ± 1.2
$P{a}_O{}_{{}_2}$, mmHg	Baseline	326 ± 11	314 ± 16	307 ± 7	285 ± 21
	30	338 ± 6	299 ± 10	305 ± 13	306 ± 15
	60	336 ± 8	287 ± 6	291 ± 15	302 ± 11
	90	336 ± 11	283 ± 10	295 ± 18	294 ± 19
sBE, mmol/l	Baseline	0.6 ± 0.4	1.9 ± 0.4	0.7 ± 0.1	0.5 ± 0.6
	30	1.1 ± 0.6	1.3 ± 0.3	1.4 ± 0.5	0.8 ± 0.6
	60	1.1 ± 0.5	0.4 ± 0.3	1.0 ± 0.7	0.4 ± 0.5
	90	0.9 ± 0.6	0.5 ± 0.6	1.4 ± 0.5	0.2 ± 0.4
MAP,mmHg	Baseline	125 ± 7	136 ± 6	103 ± 11	116 ± 6
	30	117 ± 6	138 ± 7	105 ± 11	116 ± 7
	60	117 ± 6	134 ± 7	107 ± 9	111 ± 7
	90	115 ± 6	131 ± 7	110 ± 6	109 ± 8

Values are means ± SE. $P{a}_O{}_{{}_2}$, arterial O₂ pressure; $P{a}_{CO}{}_{{}_2}$, arterial CO₂ pressure; 5-HT_2B, serotonin 2 receptor; 5-HT₇, serotonin 7 receptor; sBE, standard excess base; MAP, mean arterial pressure.