Table 3.
Upregulated kinases, E3 ligases, and transcriptional factors in response to 6 days aldosterone administration
| FPKM |
Log2- | ||||||
|---|---|---|---|---|---|---|---|
| Gene Symbol | Gene Name | Con | Aldo | Ratio | Ratio | P | Q |
| Kinase | |||||||
| Sgk1 | serine/threonine-protein kinase Sgk1 isoform a | 121.2 | 271.1 | 1.2 | 2.2 | 3.0e-03 | 2.8e-01 |
| E3 ligase | |||||||
| Herc6 | E3 ISG15-protein ligase Herc6 | 4.1 | 6.9 | 0.7 | 1.7 | 3.2e-03 | 2.8e-01 |
| Transcriptional factor | |||||||
| Irf7 | interferon regulatory factor 7 isoform 3 | 2.6 | 17.2 | 2.7 | 6.6 | 2.4e-06 | 7.9e-04 |
| Batf3 | basic leucine zipper transcriptional factor ATF-like 3 | 1.8 | 4.8 | 1.4 | 2.7 | 1.5e-02 | 6.7e-01 |
| Hmx2 | homeobox protein HMX2 | 6.1 | 14.0 | 1.2 | 2.3 | 1.2e-04 | 2.1e-02 |
| Rorc | nuclear receptor ROR-gamma | 6.1 | 12.7 | 1.1 | 2.1 | 1.2e-04 | 2.1e-02 |
| Zbtb16 | zinc finger and BTB domain-containing protein 16 | 1.9 | 3.9 | 1.0 | 2.0 | 1.1e-03 | 1.3e-01 |
| Stat1 | signal transducer and activator of transcription 1 isoform 2 | 6.2 | 11.3 | 0.9 | 1.8 | 1.2e-03 | 1.4e-01 |
| Tsc22d3 | TSC22 domain family protein 3 isoform 2 | 10.8 | 17.4 | 0.7 | 1.6 | 2.2e-02 | 7.8e-01 |
| Foxi1 | forkhead box protein I1 | 27.4 | 44.0 | 0.7 | 1.6 | 3.6e-03 | 3.0e-01 |
| Klf15 | Krüppel-like factor 15 | 8.4 | 13.1 | 0.6 | 1.6 | 1.5e-02 | 6.6e-01 |
| Stat2 | signal transducer and activator of transcription 2 | 3.4 | 5.3 | 0.6 | 1.5 | 2.2e-02 | 7.8e-01 |
| Arnt2 | aryl hydrocarbon receptor nuclear translocator 2 | 2.6 | 3.8 | 0.6 | 1.5 | 4.3e-02 | 1.0e+00 |
| Emx2 | homeobox protein EMX2 | 14.6 | 20.8 | 0.5 | 1.4 | 3.1e-02 | 8.8e-01 |
| Epas1 | endothelial PAS domain-containing protein 1 | 4.6 | 6.5 | 0.5 | 1.4 | 4.4e-02 | 1.0e+00 |
Aldo, aldosterone; Con, control; FPKM, Fragments Per Kilobase of the transcript per Million mapped reads. n = 7 per group.