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Chronic hypoxia (CH) increases basal pulmonary arterial constriction. A: basal constriction (percentage of passive inner diameter achieved by removal of extracellular Ca2+); B: vessel wall intracellular Ca2+ concentration ([Ca2+]i) [fura 2 340-to-380-nm emission ratios (F340/F380)] as a function of intraluminal pressure in endothelium-disrupted small pulmonary arteries from control and CH rats. n = 6–7/group. *P < 0.05 vs. control.
