Fig. 13.
Bay K8644 (BayK) is insufficient to drive large-amplitude contractions in mesenteric lymphatic vessels. Mesenteric lymphatic vessels were taken through the pressure step protocol first in Krebs buffer and then, after a recovery period, in the presence of 100 nM BayK. A–C: no differences were found in contraction frequency (Freq), ejection fraction (EF), or tone at any pressure. D–F: exposure to 1 μM BayK significantly increased EF, but not contraction frequency or tone, at 3 cmH2O. However, EF remained small (<20%) even with 1 μM BayK. Values are means ± SE; n = 6. *P < 0.05.