Fig. 14.

Bay K8644 (BayK) is insufficient to drive large-amplitude contractions in lymphatic thoracic duct (TD). Lymphatic TD vessels were taken through the pressure step protocol first in Krebs buffer and then, after a recovery period, in the presence of 100 nM BayK. A and B: no significant difference was found for TD contraction frequency, but EF was significantly increased at 2 and 3 cmH₂O. C: 100 nM BayK did not significantly affect tone. D–F: exposure to 1 μM BayK significantly increased EF, but not contraction frequency or tone, at 3 cmH₂O. Similar to the mesenteric vessels, EF remained at <15% even with 1 μM BayK. Values are means ± SE; n = 7. *P < 0.05.