Fig. 5.
Cardiac transient receptor potential vanilloid 1 (TRPV1) depletion increases stellate ganglion neuron (SGN) responsiveness to stress. A: 16-channel linear microelectrode array used for recording SGNs. B: a raw data channel and individual SGNs comprising the channel. Inset: the unique morphology of four SGNs is highlighted. C: mean basal SGN firing frequency in control and resiniferatoxin (RTX)-treated animals. D: mean firing rates of SGNs after termination of rapid right ventricular pacing (RVP) in control and RTX-treated animals. E: responsiveness of recorded SGNs to the stressors instituted. F: summary of changes in activity of SGNs recorded before and during each stressor. *P < 0.05; **P < 0.01; ***P < 0.001. C and D: unpaired t-test; E: χ2-test; F: Skellam-based maximum likelihood decoding.