Fig. 4.

In silico action potential (AP) biomarkers at 0.25, 1, and 3 Hz (A) and full AP traces in the Courtemanche-based population of n = 1,553 models (B) following calibration with AP biomarker data compared with ex vivo measurements. In silico population was generated with Latin hypercube sampling. In silico accepted models, i.e., those models that fulfill experimental AP calibration constraints, are plotted in dark gray; A additionally shows AP biomarkers of in silico rejected models in light gray. Ex vivo data are shown as crosses.