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Ionic processes underpinning morphologically normal Ca2+ transients (A), oscillations in diastolic Ca2+ (B), and spontaneous Ca2+ release during diastole (C) in selected Maleckar-based in silico models. In B and C, fluctuations in diastolic Ca2+ are preceded by Ca2+ release from the sarcoplasim reticulum [ryanodine receptor (RyR), bottom].
