Table 2.
Minimum and maximum bounds of action potential biomarkers, obtained from n = 29 cells ex vivo and used to calibrate the in silico populations of models
| Frequency | APD20, ms | APD50, ms | APD90, ms | RMP, mV | APA, mV | Tri90–50, ms |
|---|---|---|---|---|---|---|
| 0.25 Hz | 0.9–11.9 (5.8 ± 3.2) | 4.7–39.0 (22.0 ± 10.0) | 72.8–154.7 (113.8 ± 23.8) | −86.7 to −66.5 (−76.5 ± 5.4) | 79.7–136.5 (116.8 ± 10.9) | 56.7–121.4 (91.8 ± 19.4) |
| 0.5 Hz | 0.7–11.3 (5.6 ± 2.9) | 4.7–34.7 (21.0 ± 8.8) | 69.9–147.0 (109.3 ± 22.8) | −85.4 to −67.6 (−76.3 ± 5.1) | 86.2–133.1 (117.1 ± 9.8) | 54.2–118.9 (88.3 ± 18.8) |
| 1 Hz | 0.7–11.5 (5.5 ± 2.8) | 4.9–34.1 (20.3 ± 8.3) | 68.9–142.8 (107.8 ± 21.9) | −85.2 to −66.1 (−76.2 ± 5.1) | 94.6–137.5 (116.8 ± 9.8) | 58.3–117.6 (87.5 ± 18.0) |
| 2 Hz | 0.9–11.0 (5.5 ± 2.7) | 5.1–34.5 (19.8 ± 7.7) | 64.4–135.9 (106.1 ± 21.3) | −85.9 to −66.2 (−76.0 ± 4.5) | 100.6–130.7 (116.7 ± 8.2) | 54.9–113.5 (86.3 ± 17.9) |
| 3 Hz | 0.5–11.6 (5.4 ± 2.8) | 5.0–37.1 (19.7 ± 8.0) | 60.7–131.6 (103.9 ± 21.0) | −87.2 to −65.6 (−76.0 ± 5.2) | 92.8–132.1 (115.3 ± 9.7) | 51.5–111.4 (84.2 ± 17.7) |
Values are ranges with means ± SD in parentheses. APD20, APD50, and APD90, action potential duration at 20%, 50%, and 90% repolarization, respectively; RMP, resting membrane potential; APA, action potential amplitude; Tri90–50, triangulation.