Table 4.
Following AP + ICaL + IK1 Calibration | 90% Block Jrel | 100% Increase Jrel | Increase INCX to Normal Levels | |
---|---|---|---|---|
Number of models with spontaneous Ca2+ release | 4 | 1 | 4; more peaks and smaller amplitude of oscillations | 0 |
AP, action potential; ICaL, L-type Ca2+ current; IK1, inward rectifier K+ current; Jrel, release current; INCX, Na+/Ca2+ exchanger current. 90% block of Jrel abolishes fluctuations in 3 of 4 models; 100% increase in Jrel exacerbates diastolic Ca2+ fluctuations (more peaks in diastolic Ca2+, smaller amplitude of Ca2+ fluctuations). Increasing INCX to normal levels abolishes fluctuations in all models.