Table 4.

Number of models exhibiting fluctuations in diastolic Ca²⁺ in the Grandi-based in silico population calibrated with AP + I_CaL + I_K1 data in the absence and presence of interventions on J_rel and I_NCX.

	Following AP + ICaL + IK1 Calibration	90% Block Jrel	100% Increase Jrel	Increase INCX to Normal Levels
Number of models with spontaneous Ca2+ release	4	1	4; more peaks and smaller amplitude of oscillations	0

AP, action potential; I_CaL, L-type Ca²⁺ current; I_K1, inward rectifier K⁺ current; J_rel, release current; I_NCX, Na⁺/Ca²⁺ exchanger current. 90% block of J_rel abolishes fluctuations in 3 of 4 models; 100% increase in J_rel exacerbates diastolic Ca²⁺ fluctuations (more peaks in diastolic Ca²⁺, smaller amplitude of Ca²⁺ fluctuations). Increasing I_NCX to normal levels abolishes fluctuations in all models.