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. 2017 Dec 22;314(5):H895–H916. doi: 10.1152/ajpheart.00477.2017

Table 5.

Number of models with a spike-and-dome Ca2+ transient in the Grandi-based in silico population calibrated with AP + ICaL + IK1 data in the absence and presence of interventions on INCX, Jrel, and ICaL

Following AP + ICaL + IK1 Calibration 50% Block INCX 50% Increase Jrel 50% Increase ICaL
Number of models with a spike-and-dome Ca2+ transient 95 43 67 47
Number of models that lost spike-and-dome CaT morphology (recovering a morphologically normal Ca2+ transient) following an intervention, % NA 55% 30% 51%

AP, action potential; ICaL, L-type Ca2+ current; IK1, inward rectifier K+ current; Jrel, release current; INCX, Na+/Ca2+ exchanger current; NA, not applicable. 50% block of INCX abolishes the spike-and-dome Ca2+ transient morphology in 55% of the models, whereas 50% increase in Jrel and ICaL abolish the spike-and-dome morphology in 30% and 51% of the models.