Table 5.

Number of models with a spike-and-dome Ca²⁺ transient in the Grandi-based in silico population calibrated with AP + I_CaL + I_K1 data in the absence and presence of interventions on I_NCX, J_rel, and I_CaL

	Following AP + ICaL + IK1 Calibration	50% Block INCX	50% Increase Jrel	50% Increase ICaL
Number of models with a spike-and-dome Ca2+ transient	95	43	67	47
Number of models that lost spike-and-dome CaT morphology (recovering a morphologically normal Ca2+ transient) following an intervention, %	NA	55%	30%	51%

AP, action potential; I_CaL, L-type Ca²⁺ current; I_K1, inward rectifier K⁺ current; J_rel, release current; I_NCX, Na⁺/Ca²⁺ exchanger current; NA, not applicable. 50% block of I_NCX abolishes the spike-and-dome Ca²⁺ transient morphology in 55% of the models, whereas 50% increase in J_rel and I_CaL abolish the spike-and-dome morphology in 30% and 51% of the models.