Fig. 3.
Effect of telomerase RNA component (TERC) deletion on microvascular dilation to flow. A: mechanism of flow-mediated dilation in mesenteric arteries (MAs) of TERC knockout (KO) mice. n = 7 mice/group. *P < 0.05 at specific pressure gradients. B: dilation to papaverine (Pap) in MAs of TERC KO mice. Values are means ± SD. P = not significant vs. vehicle via two-way repeated-measures ANOVA with a post hoc Tukey test. l-NAME, Nω-nitro-l-arginine methyl ester; max, maximal; PEG-Cat, polyethylene glycol-catalase.