Skip to main content
. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Mol Immunol. 2017 Dec 19;110:3–12. doi: 10.1016/j.molimm.2017.12.003

Figure 2. Targeting macrophage biology in cancer.

Figure 2

Macrophages can mediate an array of biological activities in cancer (e.g. chemotaxis, direct cytotoxicity against tumor cells, regulation of fibrosis and vascularity as well as suppression and exclusion of T cells. Multiple molecules are associated with each of these activities and serve as targets for therapeutic intervention involving strategies that inhibit, deplete or redirect macrophages in cancer.