Table 3. Known drug - hDRG-enriched gene product interactome from DGIdb database.

Only a handful of hDRG-enriched genes have known drugs that effectively target them, suggesting further research is required into evaluating hDRG-enriched gene products as therapeutic targets. Drug databases are referenced within curly braces. Numbers within curly braces indicate related Pubmed publication IDs.

Gene	Role: Drug {reference: PUBMED ID/drug database}
CALCA	inhibitor: OLCEGEPANT {TTD, DrugBank, 17665333};
CHRNA6	agonist: CYTISINE {DrugBank, 25517706, 11553677}; NICOTINE {DrugBank, 11006350, 19560048, 20081230, 20400469}; partial agonist: VARENICLINE {DrugBank, 16766716}; unknown/NA: ETHANOL {DrugBank, 19270242, 23641218}; HEXAMETHONIUM {GuideToPharmacologyInteractions}; MECAMYLAMINE {GuideToPharmacologyInteractions};
CHRNA9	agonist: NICOTINE {DrugBank, 11006350, 19560048, 20081230, 20400469, GuideToPharmacologyInteractions, TdgClinicalTrial, TEND}; agonist/inhibitor: TETRAETHYLAMMONIUM {DrugBank, 12824448}; unknown/NA: ETHANOL {DrugBank, 19270242, 23641218}; LOBELINE {DrugBank}; MUSCARINE {GuideToPharmacologyInteractions}; STRYCHNINE {GuideToPharmacologyInteractions};
CHRNB3	agonist: NICOTINE {DrugBank, 11006350, 19560048, 20081230, 20400469}; unknown/NA: ETHANOL {DrugBank, 19270242, 23641218};
HTR3A	agonist: CISAPRIDE {DrugBank, 10328995, 1600046, 9697104, 8093733}; METOCLOPRAMIDE {DrugBank, 2955843, GuideToPharmacologyInteractions}; antagonist: ALOSETRON {DrugBank, 10776833, 20136586, 11752352, 10354345, 10848662, 10429744, 11060667, 18555935, 15061683, 17138606, 14596662, GuideToPharmacologyInteractions, TdgClinicalTrial, TEND}; ALOSETRON_HYDROCHLORIDE {ChEMBL}; AMOXAPINE {DrugBank, 1666997}; ARIPIPRAZOLE {DrugBank, 17848919}; ARVERAPAMIL {TTD}; CHLOROPROCAINE {DrugBank, 17016423, 17139284}; CLOZAPINE {DrugBank, 17848919, PharmGKB}; DDP-225 {TTD}; DOLASETRON {DrugBank, 11752352, 14635083, 1397053, 14586600, 9506240, 9341357, 8141114, 15740177, 9257083, 7493546, TTD, TdgClinicalTrial, TEND}; DOLASETRON_MESYLATE {ChEMBL}; GRANISETRON {ChEMBL, DrugBank, 12943486, 17093363, 11814868, 10882387, 11752352, 17379085, 10412832, 15740177, 16044252, TTD, GuideToPharmacologyInteractions, TdgClinicalTrial, TEND}; GRANISETRON_HYDROCHLORIDE {ChEMBL}; LERISETRON {TTD}; MEMANTINE {DrugBank, 11403963}; METHADONE {DrugBank, 19131665}; MIRTAZAPINE {DrugBank, 10446734, 11752352, 17587360, 10446735, 8930006, 11607047, TdgClinicalTrial, TEND}; OLANZAPINE {DrugBank, 17848919, TdgClinicalTrial}; ONDANSETRON_HYDROCHLORIDE {ChEMBL}; PALONOSETRON_HYDROCHLORIDE {ChEMBL}; PROCAINE {DrugBank, 7539114, 11752352, TTD}; RENZAPRIDE {TTD, DrugBank, 16696817}; ROCURONIUM {DrugBank, 10648343, TdgClinicalTrial}; TUBOCURARINE {DrugBank, 12243766, 10066903, 16723497, 1691468, 7684066, GuideToPharmacologyInteractions}; VORTIOXETINE_HYDROBROMIDE {ChEMBL, 21486038}; ZIPRASIDONE {DrugBank, 17848919}; agonist/antagonist: ONDANSETRON {ChEMBL, DrugBank, 11752352, 11919526, 17269994, 9506240, 11972287, 10065930, 19320280, 8588861, 15740177, 11763467, 20098535, 12032025, 10517265, GuideToPharmacologyInteractions, TdgClinicalTrial, TEND, TTD}; binder: LOXAPINE {DrugBank}; TRIMIPRAMINE {DrugBank, 8863001}; unknown/NA: {3H};GRANISETRON {GuideToPharmacologyInteractions}; {3H};RAMOSETRON {GuideToPharmacologyInteractions}; {3H};(S)-ZACOPRIDE {GuideToPharmacologyInteractions}; AZASETRON {GuideToPharmacologyInteractions}; BILOBALIDE {GuideToPharmacologyInteractions}; CILANSETRON {DrugBank, 16898618, 15757394, GuideToPharmacologyInteractions, TdgClinicalTrial}; COCAINE {GuideToPharmacologyInteractions}; DILTIAZEM {GuideToPharmacologyInteractions}; ESMIRTAZAPINE {TdgClinicalTrial}; ETHANOL {DrugBank, 19270242}; GINKGOLIDE_B {GuideToPharmacologyInteractions}; PALONOSETRON {GuideToPharmacologyInteractions, TdgClinicalTrial, TEND}; PICROTOXININ {GuideToPharmacologyInteractions}; PUMOSETRAG {TdgClinicalTrial}; QUETIAPINE {DrugBank, 17848919}; QUIPAZINE {GuideToPharmacologyInteractions}; RAMOSETRON {GuideToPharmacologyInteractions}; RICASETRON {GuideToPharmacologyInteractions}; (R)-ZACOPRIDE {GuideToPharmacologyInteractions}; (S)-ZACOPRIDE {GuideToPharmacologyInteractions}; TAPENTADOL {DrugBank, 10592235}; TEDATIOXETINE {TdgClinicalTrial}; TROPISETRON {GuideToPharmacologyInteractions}; VORTIOXETINE {GuideToPharmacologyInteractions, TdgClinicalTrial};
KCNK18	unknown/NA: ARACHIDONIC_ACID {GuideToPharmacologyInteractions}; DESFLURANE {ChEMBL, 15562060, 16192517, 16402123, 17227289}; ENFLURANE {ChEMBL, 16402123, 16973644, 17227289}; HALOTHANE {ChEMBL, 11605899, 11886861, 16402123, 17227289, 20217349, 20519544}; ISOFLURANE {ChEMBL, 11605899, 16402123, 17227289}; SEVOFLURANE {ChEMBL, 16402123, 21788314, 22226507};
MRGPRX1	unknown/NA: CHLOROQUINE {GuideToPharmacologyInteractions};
NTRK1	agonist: AMITRIPTYLINE {DrugBank, 19549602}; antagonist: IMATINIB {DrugBank, 17579194, 15832750, 17582306, 16052979, 16782438, TdgClinicalTrial, TEND}; inhibitor: LESTAURTINIB {TTD, TdgClinicalTrial}; REGORAFENIB {DrugBank, MyCancerGenomeClinicalTrial}; unknown/NA: DOVITINIB {ClearityFoundationClinicalTrial}; ENMD-2076 {TdgClinicalTrial};
P2RX3	unknown/NA: BZATP {GuideToPharmacologyInteractions};
QRFPR	unknown/NA: QRFP {GuideToPharmacologyInteractions};
RET	antagonist/inhibitor: CABOZANTINIB {DrugBank, 21606412, MyCancerGenomeClinicalTrial,MyCancerGenome,TALC}; inhibitor: AMUVATINIB {MyCancerGenome, TALC, TdgClinicalTrial}; AT9283 {TALC}; IMATINIB {DrugBank, 16782438, TdgClinicalTrial, TEND}; LENVATINIB {TALC}; MOTESANIB {MyCancerGenome, TALC, CIViC, 21422803}; PONATINIB {DrugBank, 23526464, MyCancerGenomeClinicalTrial}; REGORAFENIB {ChEMBL, DrugBank, MyCancerGenome, MyCancerGenomeClinicalTrial, TALC}; SORAFENIB {DrugBank, 16507829, 17016424, 15466206, MyCancerGenome, TTD, GuideToPharmacologyInteractions}; SORAFENIB_TOSYLATE {ChEMBL}; SUNITINIB {TALC, DoCM, 21470995, GuideToPharmacologyInteractions, TdgClinicalTrial, TEND}; SUNITINIB_MALATE {ChEMBL}; VANDETANIB {ChEMBL, MyCancerGenome, MyCancerGenomeClinicalTrial, TALC, TTD, ClearityFoundationClinicalTrial, DoCM, 20065189, TdgClinicalTrial}; unknown/NA: APATINIB {GuideToPharmacologyInteractions}; AZD1480 {CIViC, 23056499}; DOVITINIB {ClearityFoundationClinicalTrial}; ENMD-2076 {TdgClinicalTrial}; LINIFANIB {GuideToPharmacologyInteractions, TdgClinicalTrial};
SCN10A	blocker: DIBUCAINE_HYDROCHLORIDE {ChEMBL, 8798723, 9742684}; inhibitor: BENZOCAINE {DrugBank, 17967784, 17016423, 17139284, 16174788, 19661462, TdgClinicalTrial}; BUPIVACAINE {DrugBank, 20685573, 17016423, 17139284, TdgClinicalTrial}; CHLOROPROCAINE {DrugBank, 17016423, 8418714, 17139284, TdgClinicalTrial, TEND}; COCAINE {DrugBank, 17016423, 17139284, TdgClinicalTrial}; DYCLONINE {DrugBank, 9476974, 17016423, 17139284, 10355012, TdgClinicalTrial}; HEXYLCAINE {DrugBank, 17016423, 17139284, TdgClinicalTrial}; LEVOBUPIVACAINE {DrugBank, 11094008, 17016423, 16418020, 17139284, 10969308, TdgClinicalTrial}; LIDOCAINE {DrugBank, 17077153, 19088384, 20585544, TdgClinicalTrial, TEND}; MEPIVACAINE {DrugBank, 17016423, 20044988, 17139284, TdgClinicalTrial}; ORPHENADRINE {DrugBank, 10344632}; OXYBUPROCAINE {DrugBank, 17016423, 17139284, 19429093, TdgClinicalTrial}; PROCAINE {DrugBank, 17016423, 17139284, 9768788, 8581044, 2167458, TdgClinicalTrial}; PROPARACAINE {DrugBank, 9476974, 17016423, 17139284, TdgClinicalTrial}; ROPIVACAINE {DrugBank, 17016423, 17139284, 10781449, TdgClinicalTrial}; TETRACAINE {TTD}; unknown/NA: BATRACHOTOXIN {GuideToPharmacologyInteractions}; DIBUCAINE {TdgClinicalTrial}; LACOSAMIDE {DrugBank, 10592235}; TETRODOTOXIN {TdgClinicalTrial};
SCN11A	inhibitor: COCAINE {DrugBank, 17016423, 17139284, TdgClinicalTrial, TEND}; ZONISAMIDE {DrugBank, 20025128, 19948168, 15511691, 18433351, 20001433, 14704463, 19557119, TdgClinicalTrial}; unknown/NA: SAFINAMIDE {TdgClinicalTrial}; TETRODOTOXIN {TdgClinicalTrial};
TUBB3	inhibitor: IXABEPILONE {DrugBank, 18321240, 18945860, 18378531, TdgClinicalTrial}; unknown/NA: CYT997 {DrugBank}; DOCETAXEL {ClearityFoundationBiomarkers}; EPOTHILONE_B {DrugBank, 17016423, 17139284}; PACLITAXEL {CIViC, 21576762, ClearityFoundationBiomarkers};