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. Author manuscript; available in PMC: 2019 Jun 19.
Published in final edited form as: Biochemistry. 2018 Apr 6;57(24):3309–3325. doi: 10.1021/acs.biochem.8b00239

Figure 6.

Figure 6

Proposed mechanistic models of Alba, which catalyzes sactipeptide thioether linkage formation in the biosynthesis of subtilosin A. The first [4Fe-4S] cluster undergoes reductive cleavage of SAM. The role of the auxiliary cluster is not yet clear.