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. Author manuscript; available in PMC: 2019 Jul 28.
Published in final edited form as: J Control Release. 2018 Apr 19;282:62–75. doi: 10.1016/j.jconrel.2018.04.032

Fig. 3.

Fig. 3

(A) TEM images for the degradation of GSH-sensitive HMSiO2 NPs in the presence of 10 mM of GSH in DI water at 37 °C and pH 6 for 7 days. Control samples are the NPs dispersed in DI water at 37 °C and pH 6 after day 7 (without GSH); (B) Digital image of DOX solution (100 μg mL−1) before (left) and after (right) interaction with HMSiO2 NPs. The image was taken after mixing, washing, and precipitating the NPs via centrifugation. High loading capacity 8.9 ± 0.5% was observed with GSH-sensitive HMSiO2 NPs due to their large interior voids; (C) DOX release profile from the GSH-sensitive and TEOS HMSiO2 NPs in solutions of different pH values at 37 °C for 14 days. Control is GSH-sensitive HMSiO2 NPs dispersed in PBS at pH 6 and without GSH. Data points are mean ± SD (n = 6). **Shows there was a statistically significant difference between the two study groups (Pvalue< 0.05).