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. Author manuscript; available in PMC: 2019 Jul 28.
Published in final edited form as: J Control Release. 2018 Apr 19;282:62–75. doi: 10.1016/j.jconrel.2018.04.032

Fig. 6.

Fig. 6

Representative TEM images for intracellular co-localization of GSH-sensitive HMSiO2 NPs in MCF-7 cells: (A) Control (cells without NP treatment); (B) Cells phagocytosing the hollow particles; (C) Particles are internalized in the endocytic compartments as an individual particle or as a group of particles; (D) Cells were treated with 50 μg mL−1 of NPs and incubated for 24 h; (D1 and D2) TEM images under higher magnifications. (E) Cells were treated with 250 μg mL−1 of NPs and incubated for 24 h; (E1 and E2) TEM images under higher magnifications. Green arrows show degraded particles in endolysosomal compartments.