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. Author manuscript; available in PMC: 2019 Jul 28.
Published in final edited form as: J Control Release. 2018 Apr 19;282:62–75. doi: 10.1016/j.jconrel.2018.04.032

Fig. 7.

Fig. 7

Cytotoxicity of GSH-sensitive HMSiO2 NPs in RAW 264.7 macrophages after incubation for (A) 24 h and (B) 48 h. Particles were toxic to the cells with the concentrations equal or greater than 250 μg mL−1 GSH-sensitive HMSiO2 NP uptake rate in RAW 264.7 macrophages measured by ICP-MS in terms of (C) NP concentration and (D) incubation time (in D, cells were treated with 100 μg mL−1 of NPs). Maximum toleration threshold (5.2%) was observed when the cells where co-cultured with 75–100 μg mL−1 of NPs and incubated for 24 h. Data are mean ± SD (n = 3).