Table 3.
Comparisons Between Early Antiretroviral Therapy (Art) Initiation And Standard/Late Art Initiation With Respect To Virological Failure Among Adult Hiv Patients Who Started Art In 2012
| Baseline CD4+ count in cells/μL, n (%) | |||
|---|---|---|---|
| 200–349 | 350–499 | >500 | |
| Twelve months after initiating ART (n = 21,159) | |||
| Number of failures | 2185 (13%) | 525 (15%) | 212 (17%) |
| Number of people on treatment | 16,524 | 3421 | 1214 |
| Unadjusted OR (95% CI), p-value | 0.72 (0.62–0.84), <0.0001 | 0.86 (0.72–1.02), 0.08 | 1 |
| OR adjusted by age and sex (95% CI), p-value | 0.72 (0.61–0.84), <0.0001 | 0.86 (0.72–1.02), 0.08 | 1 |
| OR adjusted by age, sex, and transmission mode (95% CI), p-value | 0.81 (0.69–0.94), 0.007 | 0.91 (0.76–1.08), 0.28 | 1 |
| OR adjusted by all factorsa but not transmission mode (95% CI), p-value | 0.75 (0.64–0.88), 0.0003 | 0.87 (0.73–1.03), 0.11 | 1 |
| OR adjusted by all factorsa and transmission mode (95% CI), p-value | 0.81 (0.69–0.95), 0.008 | 0.90 (0.75–1.07), 0.22 | 1 |
| Twenty-four months after initiating ART (n = 17,768) | |||
| Number of failures | 1644 (11%) | 433 (14%) | 168 (16%) |
| Number of people on treatment | 13,826 | 2933 | 1009 |
| Unadjusted OR (95% CI), p-value | 0.68 (0.57–0.80), <0.0001 | 0.87 (0.71–1.05), 0.15 | 1 |
| OR adjusted by age and sex (95% CI), p-value | 0.68 (0.57–0.81), <0.0001 | 0.87 (0.72–1.06), 0.16 | 1 |
| OR adjusted by age, sex, and transmission mode (95% CI), p-value | 0.77 (0.65–0.92), 0.0038 | 0.93 (0.76–1.13), 0.48 | 1 |
| OR adjusted by all factorsa but not transmission mode (95% CI), p-value | 0.73 (0.61–0.87), 0.0004 | 0.89 (0.73–1.08), 0.22 | 1 |
| OR adjusted by all factorsa and transmission mode (95% CI), p-value | 0.78 (0.65–0.94), 0.0075 | 0.92 (0.76–1.13), 0.43 | 1 |
a
All factors here include sex, age, marital status, type of treatment center, initial ART regimen.
ART, antiretroviral therapy; CI, confidence interval; OR, odds ratio.