Table 4.

Comparison of the pharmacokinetics (AUC, C_max, half-life, and T_max) of DS-7423 between US cohort and Japanese cohort

Dose level	Study	Mean AUCtau [ng h/mL]	Mean Cmax [ng/mL]	T1/2 [h]	Tmax [h]
4	US cohort (n = 1)	21.86	4	6–7	2–4
	Japanese cohort (n = 3)	31.1	3	6–7	2–4
8	US cohort (n = 1)	131	20	6–7	2–4
	Japanese cohort (n = 3)	84.2	10	6–7	2–4
16	US cohort (n = 3)	133.5	20	6–7	2–4
	Japanese cohort (n = 2)	178	18	6–7	2–4
160	US cohort (n = 4)	1180.5	59	6–7	2–4
	Japanese cohort (n = 3)	1223.3	61	6–7	2–4
240	US cohort (n = 7)	1458.2	92.0	12	2–4
	Japanese cohort (n = 5)	1184.8	83.6	12	2–4

AUC area under the curve