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. 2018 Jun 13;10:183. doi: 10.3389/fnagi.2018.00183

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Copyright © 2018 Ueha, Ueha, Kondo, Kikuta and Yamasoba.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Representative images of immunohistological staining (brown) of SOX2⁺ olfactory receptor neurons (ORN) progenitor cells, Gap43⁺ immature ORNs, Ki67⁺ proliferating cells and cleaved caspase-3⁺ (Cas3⁺) apoptotic cells. Tissue sections were counterstained with the nuclear dye hematoxylin (blue). Arrowheads indicate Cas3⁺ apoptotic cells in the OE (n = 6). (B) Numbers of SOX2⁺ ORN progenitors and Ki67⁺ actively proliferating cells per mm of the basal layer, and Gap43⁺ immature ORNs and Cas3⁺ apoptotic cells per mm of the OE in saline or CSS-treated mice. Data represent means ± SEM (n = 6). *P < 0.05; **P < 0.01; ***P < 0.001 compared with saline-treated mice (one-way ANOVA).