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. 2018 Jun 13;9:619. doi: 10.3389/fphar.2018.00619

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Copyright © 2018 Hua, Yang, Zhang, Dong, Yu, Schwarz and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Time-kill analysis and the intracellular bacterial killing activity of aspidinol. (A) Time-kill kinetics of aspidinol against S. aureus ATCC 33591. The error bars show the standard deviations of the results from three independent biological repeats. (B) S. aureus ATCC 33591-infected RAW264.7 cells were treated with aspidinol and control antibiotics (vancomycin or linezolid) for 24 h, and the percent bacterial reduction was calculated compared to that of the untreated control groups. The results are given as the mean ± SD (n = 3). Two-tailed Student’s t-test was employed, and ^∗p-values of ≤0.05 are considered to be significant.