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. 2018 Jun 13;12:398. doi: 10.3389/fnins.2018.00398

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Copyright © 2018 Yang, Tsai, Lin and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Color map of the relative error of sample entropy (SampEn) of CSF BOLD data for appropriate selection of m and r. The SampEn relative error was defined in accordance with Lake et al. (2002) based on the 95% CI relative to the average SampEn in all CSF voxels; thus, the metric indicated the consistency of the SampEn calculation. A lower SampEn relative error indicated a higher consistency of SampEn. For example, a SampEn relative error value of 0.05 corresponds to a 95% CI, which is 10% of the average SampEn estimate. In this study, the goal was to minimize the relative error of SampEn in CSF BOLD signals because they exhibit characteristics of uncorrelated randomness and contain minimal physiologic information. The median value of the SampEn relative error for the entire study cohort is shown in color with various combinations of m, r, and scale factors.