Table 3.
Cross-sectional odd ratios (OR) and corresponding 95% confidence interval (CI) of CES-DC score above the threshold, indicating depression symptoms, according to NR3C1 methylation
| Methylation site, category | All N = 1149 |
Males N = 524 |
Females N = 625 |
|||
|---|---|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | OR | 95% CI | |
| CpG1 low | 1.47 | 0.75–2.87 | 0.72 | 0.09–5.68 | 1.77 | 0.84–3.70 |
| CpG1 high | 2.46 | 1.38–4.37 | ND | ND | 2.70 | 1.45–4.98 |
| CpG2 low | 1.23 | 0.55–2.77 | 1.10 | 0.34–8.70 | 1.34 | 0.54–3.32 |
| CpG2 high | 2.09 | 1.06–4.14 | ND | ND | 2.45 | 1.78–5.10 |
| CpG3 low | 1.09 | 0.63–1.87 | 0.69 | 0.14–3.47 | 1.12 | 0.62–2.01 |
| CpG3 high | 1.93 | 1.20–3.09 | 1.65 | 0.49–5.50 | 2.06 | 1.22–3.50 |
| CpG4 low | 1.45 | 0.57–2.29 | 1.45 | 0.31–6.81 | 1.31 | 0.59–2.91 |
| CpG4 high | 1.38 | 0.72–2.62 | 0.85 | 0.11–6.77 | 1.50 | 0.75–3.04 |
| CpG5 low | 1.94 | 0.85–4.47 | ND | ND | 2.42 | 0.99–5.92 |
| CpG5 high | 1.94 | 0.85–4.47 | ND | ND | 2.20 | 0.91–5.33 |
The Kupol Study, Stockholm 2013–2015
Reference category = unmethylated
ND not determined due to too few observations