Table 4.
Cross-sectional odds ratio (OR) and corresponding 95% confidence interval of NR3C1 CpG site 2 methylation according to potential stressors
| Potential stressors | Proportion Non-methylated (%) | Proportion Low methylated (%) | ORlow vs zero, 95% CI | Proportion High methylated (%) | ORhigh vs zero, 95% CI |
|---|---|---|---|---|---|
| Bullying | |||||
| Yes N = 180 |
83.3 | 6.7 | 1.11, 0.59–2.12 |
10.0 | 1.89, 1.08–3.32 |
| No N = 949 |
88.1 | 6.3 | Ref | 5.6 | Ref |
| Friends in school | |||||
| No N = 74 |
78.7 | 9.3 | 1.76, 0.77–4.02 |
12.0 | 2.30, 1.09–4.86 |
| Yes N = 1061 |
88.2 | 5.9 | Ref | 5.9 | Ref |
| Currently using tobacco | |||||
| Yes N = 15 |
93.3 | 6.7 | 0.99, 0.13–7.70 |
0.0 | ND |
| No N = 1134 |
87.5 | 6.3 | Ref | 6.2 | Ref |
| Alcohol the past year | |||||
| Yes N = 21 |
85.7 | 14.3 | 2.39, 0.69–8.34 |
0.0 | ND |
| No N = 1117 |
87.6 | 6.1 | Ref | 6.3 | Ref |
| Both parents’ education below university | |||||
| Yes N = 315 |
87.0 | 5.7 | 0.92, 0.53–1.60 |
7.3 | 1.30, 0.77–2.18 |
| No N = 827 |
88.0 | 6.3 | Ref | 5.7 | Ref |
| At least one parent unemployed | |||||
| Yes N = 196 |
88.8 | 4.1 | 0.62, 0.29–1.31 |
7.1 | 1.20, 0.65–2.21 |
| No N = 936 |
87.6 | 6.5 | Ref | 5.9 | Ref |
| At least one parent born outside Sweden | |||||
| Yes N = 196 |
88.3 | 5.1 | 0.80, 0.40–1.60 |
6.6 | 1.08, 0.58–2.02 |
| No N = 903 |
87.6 | 6.3 | Ref | 6.1 | Ref |
| Parents not cohabiting | |||||
| Yes N = 199 |
87.5 | 6.5 | 1.08, 0.58–2.02 |
6.0 | 1.00, 0.52–1.90 |
| No N = 923 |
87.9 | 6.1 | Ref | 6.0 | Ref |
The Kupol Study, Stockholm 2013–2015