Table 2.
Risk of obesity-related cancers according to category of weight change
| Weight changea | N | PY | Cases | I/1000 py | HR (95% CI)b |
|---|---|---|---|---|---|
| All subjects | |||||
| Weight loss | 235 | 3631 | 20 | 5.51 | 1.05 (0.65, 1.69) |
| Weight stable | 2280 | 35,901 | 173 | 4.82 | 1.00 |
| Weight gain | 1335 | 19,180 | 117 | 6.1 | 1.38 (1.09, 1.76) |
| Men | |||||
| Weight loss | 145 | 2210 | 12 | 5.43 | 1.17 (0.62, 2.18) |
| Weight stable | 1168 | 18,274 | 74 | 4.05 | 1.00 |
| Weight gain | 530 | 7568 | 34 | 4.49 | 1.32 (0.88, 2.00) |
| Women | |||||
| Weight loss | 90 | 1421 | 8 | 5.63 | 0.87 (0.41, 1.84) |
| Weight stable | 1112 | 17,627 | 99 | 5.62 | 1.00 |
| Weight gain | 805 | 11,613 | 83 | 7.15 | 1.39 (1.03, 1.87) |
CI confidence interval, I/1000 py incidence of cancer cases per 1000 person-years, HR hazards ratio.
aWeight loss = loss of 0.45 kg or more per year, weight gain = gain of 0.45 kg or more per year, weight stable = loss or gain of <0.45 kg/year.
bAdjusted for sex (for all subjects model), age, average adult height, education, cigarettes per day, alcohol intake, physical activity, and BMI at baseline