Table 3.
Risk of obesity-related cancer according to combined effect of weight change and MetDys
| Weight changea/MetDys | N | PY | Cases | I/1000 py | HR (95% CI)b |
|---|---|---|---|---|---|
| All subjects | |||||
| Weight loss or weight stable/no MetDys | 2131 | 33,908 | 161 | 4.75 | 1.00 |
| Weight gain/no MetDys | 1040 | 15,219 | 85 | 5.59 | 1.31 (1.00, 1.71) |
| Weight loss or weight stable/MetDys | 384 | 5623 | 32 | 5.69 | 1.21 (0.83, 1.78) |
| Weight gain/MetDys | 295 | 3962 | 32 | 8.08 | 1.77 (1.21, 2.59) |
| Men | |||||
| Weight loss or weight stable/no MetDys | 1047 | 16,716 | 66 | 3.95 | 1.00 |
| Weight gain/no MetDys | 385 | 5681 | 22 | 3.87 | 1.15 (0.71, 1.87) |
| Weight loss or weight stable/MetDys | 266 | 3767 | 20 | 5.31 | 1.25 (0.76, 2.08) |
| Weight gain/MetDys | 145 | 1887 | 12 | 6.36 | 1.85 (1.00, 3.44) |
| Women | |||||
| Weight loss or stability/no MetDys | 1084 | 17,192 | 95 | 5.53 | 1.00 |
| Weight gain/no MetDys | 655 | 9537 | 63 | 6.61 | 1.34 (0.97, 1.85) |
| Weight loss or stability/MetDys | 118 | 1856 | 12 | 6.47 | 1.09 (0.60, 1.99) |
| Weight gain/MetDys | 150 | 2075 | 20 | 9.64 | 1.74 (1.07, 2.82) |
CI confidence interval, HR hazards ratio, I/1000 py incidence of cancer cases per 1000 person-years, MetDys metabolic dysfunction.
aWeight loss = loss of 0.45 kg or more per year, weight gain = gain of 0.45 kg or more per year; weight stable = loss or gain of <0.45 kg/year.
bAdjusted for sex (for all subjects model), age, average adult height, education, cigarettes per day, alcohol intake and physical activity