Fig. 3.

Overall survival. OS in 545 and 494 patients with different baseline serum levels of CEA and CA 19-9, respectively (a–c). a Serum level of CEA <5 µg/L or CEA ≥5 µg/L. b Serum level of CA 19-9 <35 kU/L or CA 19-9 ≥35 kU/L. c Serum level of CA 19-9 level <35 kU/L or CA 19-9 ≥35 kU/L in patients with CEA level <5 µg/L or CEA ≥5 µg/L. d OS in 51 patients with BRAF-mutant tumours; CA 19-9 level <35 kU/L or CA 19-9 ≥35 kU/L. OS overall survival, HR hazard ratio, CI confidence interval