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. 2018 Jun 19;8:9370. doi: 10.1038/s41598-018-27627-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Distribution of gene activity of the four genes up-regulated to the greatest extent in areas of inflammatory cells compared to areas without inflammatory cells. The gene expression distribution of immunoglobulin lambda-like polypeptide 5 (IGLL5), signal sequence receptor subunit 4 (SSR4), marginal zone B and B1 cell specific protein (MZB1) and X-box binding protein 1 (XBP1) are shown. Yellow spots correspond to low expression of IGLL5, SSR4, MZB1, or XBP1, whereas red spots correspond to high gene expression. All count values have been normalized and log2 transformed.