Table 2.
Ki values for benzamidopyridin-2-one library against Aurora A, Aurora B and MPS1.
| Compd | MPS1 Ki µM (LE) | AurA Ki µM (LE) | AurB Ki µM (LE) |
|---|---|---|---|
| 16 | 5.4 (0.33) | 3.3 (0.34) | 41.0 (0.27) |
| 17 | 24.8 (0.26) | >100 (-) | >100 (-) |
| 18 | 30.1 (0.24) | >100 (-) | 32.9 (0.23) |
| 19 | >100 (-) | >100 (-) | >100 (-) |
| 20 | >100 (-) | >100 (-) | >100 (-) |
| 21 | >100 (-) | >100 (-) | >100 (-) |
| 22 | 4.8 (0.25) | 14.9 (0.23) | 5.5 (0.25) |
| 23 | 2.9 (0.27) | 2.6 (0.27) | 7.4 (0.25) |
| 24 | 3.2 (0.29) | 17.3 (0.25) | 3.6 (0.28) |
Ki values were calculated from IC50 values using the Cheng-Prusoff equation.48