Fig. 1.

CONSORT flow diagram.

CONSORT flow diagram of patients enrolled in the CE-MARC 2 microvascular sub-study. Of 1202 patients enrolled into the CE-MARC 2 trial, 267 (22.2%) underwent invasive coronary angiography and 119 (45%) of these patients had an indication for FFR measurement. Thirty-eight (32%) of these patients did not have FFR measured for the following reasons: severe obstructive CAD, n = 15; urgent invasive management, n = 3; clinical and technical factors, n = 20. Eighty-one patients had FFR measured in at least one coronary artery (115 vessels) and additional parameters of microvascular function were available for 63/81 (78%) patients in 85 vessels. Overall, 63 patients had coronary microvascular function assessed, including 22, 18 and 23 patients randomised to CMR-guided, MPS-guided and NICE management-guided care, respectively.

FFR = fractional flow reserve.