Table 4.
Amino acid distributions in CDRs 1–3.
| CDR1 (IMGT 27–38) | CDR2 (IMGT 56–65) | CDR3 (IMGT 105–117), 12–15AA | ||||
|---|---|---|---|---|---|---|
| SynVH-C (%) | SynVH-SD (%) | SynVH-C (%) | SynVH-SD (%) | SynVH-C (%) | SynVH-SD (%) | |
| D | 5.24 | 12.16 | 5.04 | 4.44 | 11.50 | 11.64 |
| E | 0.05 | 0.00 | 0.59 | 0.28 | 2.08 | 1.02 |
| K | 0.12 | 0.15 | 0.26 | 1.16 | 6.53 | 5.56 |
| R | 1.53 | 0.57 | 2.43 | 1.54 | 4.51 | 3.80 |
| H | 2.68 | 0.71 | 0.60 | 0.32 | 0.60 | 3.46 |
| T | 12.11 | 11.98 | 12.80 | 14.07 | 5.94 | 4.01 |
| S | 17.70 | 14.85 | 23.92 | 23.46 | 8.05 | 3.15 |
| N | 3.80 | 3.10 | 5.02 | 9.72 | 6.89 | 4.84 |
| Q | 0.00 | 0.04 | 0.06 | 0.05 | 0.17 | 2.29 |
| G | 14.74 | 13.67 | 23.94 | 19.35 | 6.56 | 4.25* |
| A | 6.39 | 2.10 | 6.06 | 1.56 | 8.84 | 9.64 |
| C | 0.00 | 0.03 | 0.04 | 0.00 | 0.05 | 1.28 |
| P | 0.43 | 0.47 | 0.51 | 0.15 | 1.24 | 1.80 |
| V | 0.56 | 0.65 | 2.13 | 1.03 | 2.14 | 10.32* |
| I | 1.20 | 0.32 | 14.52 | 14.85 | 1.74 | 1.73 |
| L | 0.78 | 0.37 | 0.69 | 0.28 | 1.26 | 1.96 |
| M | 0.04 | 0.00 | 0.06 | 0.08 | 0.32 | 8.25* |
| F | 24.26 | 24.11 | 0.17 | 0.09 | 14.65* | 1.03 |
| Y | 8.35 | 11.43 | 1.14 | 3.39 | 10.90 | 18.59 |
| W | 0 | 3.27 | 0.04 | 4.17 | 6.05 | 1.38 |
IMGT CDR designations were used. For CDR-H3, amino acid frequencies in CDR lengths of 12–15 residues were calculated and averaged. Asterisk (*) indicates those CDR3 residues that are specific to either JH4 (SynVH-C) or JH6 (SynVH-SD). Only the human sequences were analyzed from the six SynVH-C birds (n = 5,652) and three SynVH-SD birds (n = 3,000).