Table 6.
Characteristics of the 12 definitec AE patients missed by the clinical algorithm.
| Sex | Age (years) | Antibody | Site of antibody detection | Main clinical complaints | T0–T1 (days) | Follow-up (days) | MRI—increased FLAIR signal | EEG | CSF—Pleocyt. (cells/μl) | Tumor |
|---|---|---|---|---|---|---|---|---|---|---|
| Male | 57 | CASPR2 | Serum, CSF | Cognitive symptoms, seizures | 180 | 1,077 | Left amygdala | Left temporal epileptic discharges | Yes (7) | No |
| Male | 30 | Ma2 | Serum, CSF | Cognitive symptoms, psychiatric alterations, seizures | 150 | 987 | Left temporomesial | Epileptic discharges | Yes (5) | No |
| Female | 57 | Ri | Serum | Opsoclonus | 56 | 638 | Microangiopathy | Not done | Yes (64) | Cancer of unknown origin |
| Male | 73 | LGI1 | Serum | Seizures, autonomic symptoms | 49 | 1,619 | Right (para-) hippocampus | Epileptic discharges | No | Prostate carcinoma |
| Male | 65 | GABA B | Serum | Seizures, facial palsy | 14 | 350 | Normal | General slowing | No | No |
| Female | 67 | LGI1 | Serum, CSF | Seizures | 8 | 920 | Right amygdala and hippocampus | General slowing | Yes (11) | No |
| Male | 40 | NMDAR | Serum, CSF | Seizures, dysarthria, dysphagia | 7 | 385 | Bilateral (sub) cortical | Epileptic discharges | No | No |
| Male | 72 | CASPR2 | Serum, CSF | Seizures | 150 | 427 | Right hippocampus | Regional slowing | No | No |
| Male | 65 | LGI1 | Serum | Seizures | 21 | 267 | Microangiopathy | Normal | No | No |
| Female | 70 | SOX1, Amphiphysin | Serum, CSF | Seizures, hemiparesis | 10 | 881 | Normal | Epileptic discharges | No | Neuroendocrine bronchial carcinoma |
| Male | 64 | CASPR2 | Serum, CSF | Seizures | 1 | 2,321 | Normal | Normal | No | No |
| Female | 39 | LGI1 | Serum | Cognitive symptoms, psychiatric alterations, seizures | 270 | 1,431 | Normal | Not done | No | No |