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. 2018 Jun 8;9:428. doi: 10.3389/fneur.2018.00428

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Copyright © 2018 Riemann, Younsi, Scherer, Zheng, Skutella, Unterberg and Zweckberger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GFP-positive NPCs (green) and Iba1-positive macrophages (red) in the injured spinal cord 8 weeks after traumatic cervical SCI (n = 7). (A) GFP-positive NPCs were mainly distributed in the dorsal white and gray matter (10 × magnification, scale bar = 500 μm). (B) Additionally, GFP-expressing NPCs were often located very close to Iba1-positive macrophages (40 × magnification, scale bar = 15 μm). (C) Surviving NPCs differentiated primarily along the oligodendroglial lineage (GFP/APC), while only a minority of NPCs differentiated into neurons (GFP/NeuN).