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Functional properties of Shh and of mutated constructs and effects of mAbs on Shh
| Treatment | Patched binding | Induction of motoneurons in neural plate explant | Inhibition of NCC migration |
|---|---|---|---|
| Shh | +++ | +++ | +++ |
| Shh(polyQ) | − | − | − |
| Shh(N-9/C-3) | +++ | +++ | − |
| Shh + mAb ASC1 | − | − | − |
| Shh + mAb 5E1 | − | − | +++ |
Data on patched binding and induction of motoneurons in neural plate explants have been published elsewhere (17).
