Skip to main content
. 2018 Jun 4;2018:9362108. doi: 10.1155/2018/9362108

Table 2.

Characteristics of patients and hazard ratios (HR) (95% confidence interval [95%CI]) of mitotane in multivariate Cox regression model fitted for time of recurrence-free survival (RFS) and overall survival (OS), adjusted by age, gender, stage, positive surgical margins (PSMs), functional status and/or adjuvant radiation, etc.

Reference Year Total No. Age/ya Male/% Stage IV/%b PSMs/%c Function/% Radiation/% Mitotaned RFS/HR(95%CI)e OS /HR(95%CI)e
Berruti [16] 2017 92 43 32 11 - 45 0 47 1/2.98(1.75-5.09) 1/2.03(1.17-3.51)
Postlewait [27] 2016 169g 51 39 31 31 43 10 56 1.4(0.8-2.4) 0.7(0.3-1.5)
Berruti [28] 2014 524 45 39 0 0 52 - 251 0.66(0.53-0.83) 0.82(0.60-1.10)
Grubbs [29] 2010 215 46 35 4 27 55 - 19 1/1.96(1.07-3.61) 1/1.58(0.75-3.31)
Fassnacht [30] 2010 149 48 35 0 9 - 9 35 0.58(0.29-1.15) 0.38(0.12-1.28)

a Median or mean age of total population.

b Local advanced cases without distant metastasis.

c (R1+R2) / (R0+R1+R2) (R0 denotes microscopically negative margin; R1 denotes microscopically positive margin; R2 denotes grossly positive margin) in spite of Rx or data loss.

d Number of patients who received mitotane.

e HR of mitotane relative to nonmitotane. When a study provided HR of no mitotane relative to mitotane, it was recorded as 1/HR.