Table 4.
Effect of Essential oil of Isodon rugosus on hot plate induced pain in mice.
| Samples | Dose (mg/kg) | Reaction time on hot plate | ||||
|---|---|---|---|---|---|---|
| 15 min | 30 min | 45 min | 60 min | 90 min | ||
| Negative cont. | – | 04.51 ± 0.10 | 02.43 ± 0.14 | 03.55 ± 0.07 | 02.11 ± 0.15 | 03.20 ± 0.15 |
| Ir.Eo | 50 | 06.40 ± 0.11 | 04.18 ± 0.11 | 05.76 ± 0.08 | 04.81 ± 0.14 | 04.40 ± 0.20 |
| Ir.Eo | 100 | 08.16 ± 0.08 | 06.81 ± 0.13 | 07.91 ± 0.11 | 06.80 ± 0.07 | 06.45 ± 0.07 |
| Mor | 5 | 12.41 ± 0.11 | 11.63 ± 0.06 | 11.36 ± 0.08 | 10.45 ± 0.07 | 09.38 ± 0.08 |
| Mor + Nal | 5 + 1 | 04.35 ± 0.13 | 02.80 ± 0.19 | 04.35 ± 0.07 | 02.78 ± 0.10 | 03.56 ± 0.14 |
| Ir.Eo + Nal | 50 + 1 | 05.28 ± 0.13 | 03.31 ± 0.08 | 04.70 ± 0.08 | 03.11 ± 0.15 | 03.70 ± 0.05 |
Ir.Eo: Essential oil of Isodon rugosus; Mor: Morphine; Nal: Naloxone; Total time is represented as mean ± SEM.