Table 1.
Week | Control | ANG II-salt | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Vehicle | Benzbromarone | Olmesartan | ||||||||||
0 | 2 | 4 | 0 | 2 | 4 | 0 | 2 | 4 | 0 | 2 | 4 | |
Body weight (g) | 209 ± 13 | 348 ± 16 | 405 ± 41 | 205 ± 13 | 204 ± 33∗ | 197 ± 42∗ | 205 ± 12 | 239 ± 31∗ | 224 ± 50∗ | 208 ± 14 | 304 ± 14∗,# | 363 ± 21# |
TP (g/dL) | 5.7 ± 0.2 | 5.8 ± 0.1 | 6.0 ± 0.2 | 5.4 ± 0.2 | 5.7 ± 0.6 | 5.9 ± 0.5 | 5.4 ± 0.3 | 5.5 ± 0.6 | 6.1 ± 0.8 | 5.6 ± 0.1 | 6.0 ± 0.4 | 6.4 ± 0.4 |
UA (mg/dL) | 0.48 ± 0.14 | 0.78 ± 0.34 | 0.68 ± 0.19 | 0.49 ± 0.22 | 0.63 ± 0.59 | 1.77 ± 1.22∗ | 0.53 ± 0.27 | 0.89 ± 0.43 | 1.04 ± 0.29 | 0.40 ± 0.14 | 0.92 ± 0.44 | 0.56 ± 0.34# |
Cr (mg/dL) | 0.54 ± 0.12 | 0.79 ± 0.17 | 0.45 ± 0.12 | 0.50 ± 0.23 | 0.74 ± 0.23 | 0.84 ± 0.48 | 0.61 ± 0.18 | 0.47 ± 0.35 | 0.95 ± 0.69 | 0.48 ± 0.07 | 0.87 ± 0.59 | 0.61 ± 0.37 |
BUN (mg/dL) | 22.1 ± 10.9 | 16.5 ± 3.0 | 22.1 ± 3.4 | 22.6 ± 10.2 | 35.5 ± 10.2∗ | 42.0 ± 33.8 | 20.4 ± 6.9 | 39.6 ± 6.3∗ | 42.2 ± 21.1 | 18.1 ± 7.4 | 21.5 ± 4.8# | 24.5 ± 6.3 |
AST (IU/L) | 28.8 ± 1.8 | 30.6 ± 4.9 | 28.8 ± 3.6 | 31.2 ± 3.8 | 29.5 ± 2.5 | 31.6 ± 10.2 | 30.9 ± 3.6 | 34.8 ± 12.1 | 42.0 ± 19.6 | 29.6 ± 4.0 | 32.9 ± 3.3 | 27.5 ± 2.2 |
ALT (IU/L) | 7.5 ± 1.5 | 7.6 ± 1.0 | 8.2 ± 1.1 | 7.7 ± 0.9 | 9.7 ± 2.7 | 18.6 ± 5.6∗ | 7.8 ± 1.1 | 11.1 ± 3.3 | 16.5 ± 7.2∗ | 7.1 ± 1.4 | 9.3 ± 1.4 | 9.4 ± 2.1# |
U-pro (mg/day) | 4 ± 2 | 8 ± 2 | 9 ± 2 | 4 ± 2 | 313 ± 170∗ | 255 ± 278∗ | 4 ± 3 | 255 ± 100∗ | 255 ± 88∗ | 5 ± 3 | 14 ± 8# | 18 ± 11# |
Values are expressed as the means ± SD (control, n = 5, others, n = 3–11). ∗P < 0.05 compared with the control group, #P < 0.05 compared with the vehicle group at the same week.