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. 2018 Jun 5;2018:7635274. doi: 10.1155/2018/7635274

Table 1.

Physiological parameters at 0, 2, and 4 weeks.

Week Control ANG II-salt
Vehicle Benzbromarone Olmesartan
0 2 4 0 2 4 0 2 4 0 2 4
Body weight (g) 209 ± 13 348 ± 16 405 ± 41 205 ± 13 204 ± 33 197 ± 42 205 ± 12 239 ± 31 224 ± 50 208 ± 14 304 ± 14,# 363 ± 21#
TP (g/dL) 5.7 ± 0.2 5.8 ± 0.1 6.0 ± 0.2 5.4 ± 0.2 5.7 ± 0.6 5.9 ± 0.5 5.4 ± 0.3 5.5 ± 0.6 6.1 ± 0.8 5.6 ± 0.1 6.0 ± 0.4 6.4 ± 0.4
UA (mg/dL) 0.48 ± 0.14 0.78 ± 0.34 0.68 ± 0.19 0.49 ± 0.22 0.63 ± 0.59 1.77 ± 1.22 0.53 ± 0.27 0.89 ± 0.43 1.04 ± 0.29 0.40 ± 0.14 0.92 ± 0.44 0.56 ± 0.34#
Cr (mg/dL) 0.54 ± 0.12 0.79 ± 0.17 0.45 ± 0.12 0.50 ± 0.23 0.74 ± 0.23 0.84 ± 0.48 0.61 ± 0.18 0.47 ± 0.35 0.95 ± 0.69 0.48 ± 0.07 0.87 ± 0.59 0.61 ± 0.37
BUN (mg/dL) 22.1 ± 10.9 16.5 ± 3.0 22.1 ± 3.4 22.6 ± 10.2 35.5 ± 10.2 42.0 ± 33.8 20.4 ± 6.9 39.6 ± 6.3 42.2 ± 21.1 18.1 ± 7.4 21.5 ± 4.8# 24.5 ± 6.3
AST (IU/L) 28.8 ± 1.8 30.6 ± 4.9 28.8 ± 3.6 31.2 ± 3.8 29.5 ± 2.5 31.6 ± 10.2 30.9 ± 3.6 34.8 ± 12.1 42.0 ± 19.6 29.6 ± 4.0 32.9 ± 3.3 27.5 ± 2.2
ALT (IU/L) 7.5 ± 1.5 7.6 ± 1.0 8.2 ± 1.1 7.7 ± 0.9 9.7 ± 2.7 18.6 ± 5.6 7.8 ± 1.1 11.1 ± 3.3 16.5 ± 7.2 7.1 ± 1.4 9.3 ± 1.4 9.4 ± 2.1#
U-pro (mg/day) 4 ± 2 8 ± 2 9 ± 2 4 ± 2 313 ± 170 255 ± 278 4 ± 3 255 ± 100 255 ± 88 5 ± 3 14 ± 8# 18 ± 11#

Values are expressed as the means ± SD (control, n = 5, others, n = 3–11). P < 0.05 compared with the control group, #P < 0.05 compared with the vehicle group at the same week.